Ca2+-activated Cl current predominates in threshold response of mouse olfactory receptor neurons
نویسندگان
چکیده
منابع مشابه
Ca2+-activated Cl- conductance of fish olfactory neurons
transduction in olfactory receptor neurons (ORNs) is mediated by multiple second-messenger pathways: cyclic AMP and inositol 1,4,5-trisphosphate (InsP3) pathways. Odorant binding to G-protein-coupled receptors (Buck and Axel, 1991) is the initial event of olfactory transduction, and this in turn results in the activation of adenylate cyclase or phospholipase C to produce the second messenger, c...
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Olfactory transduction in vertebrate olfactory receptor neurons (ORNs) involves primarily a cAMP-signaling cascade that leads to the opening of cyclic-nucleotide-gated (CNG), nonselective cation channels. The consequent Ca2+ influx triggers adaptation but also signal amplification, the latter by opening a Ca2+-activated Cl channel (ANO2) to elicit, unusually, an inward Cl current. Hence the olf...
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The sense of smell begins with odorant molecules binding to membrane receptors on the cilia of olfactory receptor neurons (ORNs), thereby activating a G protein, G(olf), and the downstream effector enzyme, an adenylyl cyclase (ACIII). Recently, we have found in amphibian ORNs that an odorant-binding event has a low probability of activating sensory transduction at all; even when successful, the...
متن کاملMechanism of the Excitatory Cl− Response in Mouse Olfactory Receptor Neurons
In vertebrate olfactory receptor neurons (ORNs), the odorant-triggered receptor current flows through two distinct ion channels on the sensory cilia: Ca2+ influx through a cyclic nucleotide-gated (CNG) channel followed by Cl- efflux through a Ca2+-activated anion channel. The excitatory Cl- current amplifies the small CNG current and crucially depends on a high intracellular Cl- concentration. ...
متن کاملBestrophin-Encoded Ca2+-Activated Cl− Channels Underlie a Current with Properties Similar to the Native Current in the Moth Spodoptera littoralis Olfactory Receptor Neurons
Responses of insect olfactory receptor neurons (ORNs) involve an entry of Ca²⁺ through olfactory heterodimeric receptor complexes. In moths, the termination of ORN responses was found to strongly depend on the external Ca²⁺ concentration through the activation of unknown Ca²⁺-dependent Cl⁻ channels. We thus investigated the molecular identity of these Cl⁻ channels. There is compelling evidence ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2018
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1803443115